Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.

@article{Marchant2009BosentanEV,
  title={Bosentan enhances viral load via endothelin-1 receptor type-A-mediated p38 mitogen-activated protein kinase activation while improving cardiac function during coxsackievirus-induced myocarditis.},
  author={David J Marchant and Ying Dou and Honglin Luo and Farshid S. Garmaroudi and John E McDonough and Xiaoning Si and Elizabeth Walker and Zongshu Luo and Anders Arner and Richard G. Hegele and Ismail Laher and Bruce McManus},
  journal={Circulation research},
  year={2009},
  volume={104 6},
  pages={813-21}
}
Reduced cardiac output is one of the consequences of myocarditis. Bosentan, an endothelin-1 receptor (ET1R) antagonist, could be useful to reduce cardiac afterload, preserving cardiac output. In this study, we investigated the potential therapeutic use of bosentan in an animal model of viral myocarditis. Using a mouse model of coxsackievirus B3 (CVB3)-induced myocarditis, we demonstrated preserved ejection fraction (EF) and fractional shortening (FS) by treatment with bosentan (68+/-5.8% EF and… CONTINUE READING
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