Bortezomib suppresses the growth of leukemia cells with Notch1 overexpression in vivo and in vitro

@article{Huang2012BortezomibST,
  title={Bortezomib suppresses the growth of leukemia cells with Notch1 overexpression in vivo and in vitro},
  author={Chongmei Huang and Xiaoxia Hu and Libing Wang and Shuqing L{\"u} and Hongyan Cheng and Xianmin Song and Jianmin Wang and Jianmin Yang},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2012},
  volume={70},
  pages={801-809}
}
Bortezomib has been widely used in the treatment of various cancers; however, its exact mechanisms of action are not fully understood, particularly in acute T lymphoblast leukemia (T-ALL). Here, we visualize the anti-leukemia effect of bortezomib in both human T-ALL cell line and animal models. In vitro study, a human T-ALL cell line bearing Notch1 mutations, MOLT-4, was treated with bortezomib. At clinically achievable concentrations, bortezomib inhibited cell growth by inducing G1 phase… CONTINUE READING

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