Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells

@article{Min2014BortezomibIP,
  title={Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells},
  author={Han Min and Min Xu and Zhi-Rong Chen and Jun-dong Zhou and Min Huang and Kai Zheng and Xiaoping Zou},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2014},
  volume={74},
  pages={167-176}
}
Bortezomib, a selective and potent inhibitor of the proteasome, has demonstrated broad anti-tumor activities in many malignancies. In the current study, we aimed to understand the potential resistance factor of bortezomib in cultured pancreatic and colorectal cancer cells. We observed that bortezomib-induced protective autophagy in cultured PANC-1 pancreatic cancer cells and HT-29 colorectal cancer cells. Inhibition of autophagy by 3-methyladenine (3-MA) and chloroquine enhanced bortezomib… CONTINUE READING

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