Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.

@article{Liu2008BortezomibID,
  title={Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.},
  author={Shujun Liu and Zhongfa Liu and Zhiliang Xie and Jiuxia Pang and Jianhua Yu and Esther Lehmann and Lenguyen Huynh and Tamara Vukosavljevic and Mitsui Takeki and Rebecca B. Klisovic and Robert A Baiocchi and William Blum and Pierluigi Porcu and Reinhold Munker and John C. Byrd and Danilo Perrotti and Michael A. Caligiuri and Kenneth Ka-Sing Chan and Lai-Chu Wu and Guido Marcucci},
  journal={Blood},
  year={2008},
  volume={111 4},
  pages={
          2364-73
        }
}
Bortezomib reversibly inhibits 26S proteasomal degradation, interferes with NF-kappaB, and exhibits antitumor activity in human malignancies. Zinc finger protein Sp1 transactivates DNMT1 gene in mice and is functionally regulated through protein abundance, posttranslational modifications (ie, ubiquitination), or interaction with other transcription factors (ie, NF-kappaB). We hypothesize that inhibition of proteasomal degradation and Sp1/NF-kappaB-mediated transactivation may impair aberrant… CONTINUE READING

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