Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat.

@article{Cavaletti2007BortezomibinducedPN,
  title={Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat.},
  author={Guido Cavaletti and Alessandra Gilardini and Annalisa Canta and Laura Maria Rigamonti and Virginia Rodriguez-Menendez and Cecilia Ceresa and Paola Marmiroli and Mario Bossi and Norberto Oggioni and Maurizio D'Incalci and Roland De Coster},
  journal={Experimental neurology},
  year={2007},
  volume={204 1},
  pages={317-25}
}
Bortezomib is a new proteasome inhibitor with a high antitumor activity, but also with a potentially severe peripheral neurotoxicity. To establish a preclinical model and to characterize the changes induced on the peripheral nerves, dorsal root ganglia (DRG) and spinal cord, bortezomib was administered to Wistar rats (0.08, 0.15, 0.20, 0.30 mg/kg/day twice [2q7d] or three times [3q7d] weekly for a total of 4 weeks). At baseline, on days 14, 21 and 28 after the beginning the treatment period and… CONTINUE READING
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