Bortezomib attenuates murine collagen-induced arthritis.

Abstract

OBJECTIVES Nuclear factor kappa B (NF-kappaB) is a major regulator of pivotal proinflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA). Bortezomib inhibits NF-kappaB activation by blocking the degradation of the NF-kappaB inhibitor, I-kappaB. In this study, the efficacy of bortezomib on murine collagen-induced arthritis (CIA) was… (More)
DOI: 10.1136/ard.2008.097709

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