Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

@article{Uddin2008BortezomibI,
  title={Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.},
  author={Shahab Uddin and M El-Garhy Ahmed and Prashant Bavi and Raafat M. El-Sayed and Nasser A. Al-Sanea and Alaa Abduljabbar and Luai H. S. Ashari and Samar J Alhomoud and Fouad Hassan Al-Dayel and Azhar R. Hussain and Khawla S Al-Kuraya},
  journal={Cancer research},
  year={2008},
  volume={68 9},
  pages={
          3379-88
        }
}
S-phase kinase protein 2 (SKP2), an F-box protein, targets cell cycle regulators including cycle-dependent kinase inhibitor p27Kip1 via ubiquitin-mediated degradation. SKP2 is frequently overexpressed in a variety of cancers. We investigated the role of SKP2 and its ubiquitin-proteasome pathway in colorectal carcinoma using a panel of cell lines, clinical samples, and the NUDE mouse model. Using immunohistochemical analysis on a large tissue microarray of 448 samples, an inverse association of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

American Association for Cancer cancerres.aacrjournals.org Downloaded from Cancer

AR Hussain, M Al-Rasheed, PS Manogaran
  • Research. on April
  • 2008
VIEW 2 EXCERPTS

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer

G Chiappetta, C De Marco, A Quintiero
  • Endocr Relat Cancer 2007;14:405–20
  • 2007
VIEW 1 EXCERPT

NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2006
VIEW 1 EXCERPT

Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis.

  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 2006

Role of phosphatidylinositol 3’-kinase/AKT pathway in diffuse large B-cell lymphoma survival

S Uddin, AR Hussain, KA Al-Hussein
  • Blood
  • 2006
VIEW 1 EXCERPT