Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.

@article{Uddin2008BortezomibI,
  title={Bortezomib (Velcade) induces p27Kip1 expression through S-phase kinase protein 2 degradation in colorectal cancer.},
  author={Shahab Uddin and Maqbool Ahmed and Prashant Bavi and Raafat M. El-Sayed and Nasser A. Al-Sanea and Alaa Abduljabbar and Luai H S Ashari and Samar J Alhomoud and Fouad Hassan Al-Dayel and Azhar R. Hussain and Khawla S Al-Kuraya},
  journal={Cancer research},
  year={2008},
  volume={68 9},
  pages={3379-88}
}
S-phase kinase protein 2 (SKP2), an F-box protein, targets cell cycle regulators including cycle-dependent kinase inhibitor p27Kip1 via ubiquitin-mediated degradation. SKP2 is frequently overexpressed in a variety of cancers. We investigated the role of SKP2 and its ubiquitin-proteasome pathway in colorectal carcinoma using a panel of cell lines, clinical samples, and the NUDE mouse model. Using immunohistochemical analysis on a large tissue microarray of 448 samples, an inverse association of… CONTINUE READING
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