Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content.

@article{Sarkar2009BorreliaBR,
  title={Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content.},
  author={Amit Sarkar and Kit Tilly and Philip E Stewart and Aaron C Bestor and James M. Battisti and Patricia A Rosa},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={4490-4}
}
We hypothesize a potential role for Borrelia burgdorferi OspC in innate immune evasion at the initial stage of mammalian infection. We demonstrate that B. burgdorferi is resistant to high levels (>200 microg/ml) of cathelicidin and that this antimicrobial peptide exhibits limited binding to the spirochetal outer membrane, irrespective of OspC or other abundant surface lipoproteins. We conclude that the essential role of OspC is unrelated to resistance to this component of innate immunity. 
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