Borrelia burgdorferi induces secretion of pro-urokinase-type plasminogen activator by human monocytes.

@article{Fuchs1996BorreliaBI,
  title={Borrelia burgdorferi induces secretion of pro-urokinase-type plasminogen activator by human monocytes.},
  author={H M Fuchs and Markus Michael Simon and Reinhard Wallich and Michael J. Bechtel and Michael D. Kramer},
  journal={Infection and immunity},
  year={1996},
  volume={64 10},
  pages={4307-12}
}
Borrelia burgdorferi is transmitted by infected ticks and causes Lyme disease. To infect distant organ sites, B. burgdorferi spirochetes must disseminate from the site of the tick bite. During dissemination from the dermal tissue, they breach tissue barriers, probably by proteolysis. The previous findings that spirochetes bind serum-derived plasminogen and that plasmin favors spirochetal invasiveness and infectivity suggested a role for plasmin in the pathogenicity of B. burgdorferi. Binding of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…