Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature.

@article{Obonyo1999BorreliaBI,
  title={Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature.},
  author={Marygorret Obonyo and Ulrike Gertrud Munderloh and Volker Fingerle and Bettina Wilske and Timothy J. Kurtti},
  journal={Journal of clinical microbiology},
  year={1999},
  volume={37 7},
  pages={2137-41}
}
The Lyme disease spirochete Borrelia burgdorferi sensu stricto downregulates outer surface protein A (OspA) and upregulates outer surface protein C (OspC) during tick feeding. The switching of these proteins correlates with increased spirochetal infectivity for the mammal. We examined the effect of temperature on differential expression of OspA and OspC by B. burgdorferi cocultivated with a cell line isolated from the vector tick Ixodes scapularis. The effect of incubation at 31, 34, or 37… CONTINUE READING