Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers.

@article{Coleman1995BorreliaBB,
  title={Borrelia burgdorferi binds plasminogen, resulting in enhanced penetration of endothelial monolayers.},
  author={James L. Coleman and Timothy J. Sellati and Jacqueline E. Testa and Richard R. Kew and Martha B. Furie and Jorge L. Benach},
  journal={Infection and immunity},
  year={1995},
  volume={63 7},
  pages={2478-84}
}
Several strains of Borrelia burgdorferi and Borrelia hermsii can bind human Lys-plasminogen specifically. Affinity blots using 125I-labeled plasminogen showed that numerous polypeptides of all the strains and species tested could bind via lysine residues to the plasminogen molecule since binding could be completely inhibited by the lysine analog epsilon-aminocaproic acid. Binding analysis using 125I-labeled plasminogen on live intact organisms showed that the organisms possess two binding sites… CONTINUE READING

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PLASMIN-COATED B. BURGDORFERI PENETRATES ENDOTHELIUM 2483 on F ebuary 21

  • A. J. Huang, M. B. Furie, S. C. Nicholson, J. Fischbarg, L. S. Liebovitch, VOL
  • .rg/ D ow nladed fom and S. C. Silverstein
  • 1995
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