Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection.

@article{Tilly2006BorreliaBO,
  title={Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection.},
  author={Kit Tilly and Jonathan G. Krum and Aaron C Bestor and Mollie W Jewett and Dorothee Grimm and Dawn M Bueschel and Rebecca Byram and David Dorward and Mark J Vanraden and Philip E Stewart and Patricia A Rosa},
  journal={Infection and immunity},
  year={2006},
  volume={74 6},
  pages={
          3554-64
        }
}
This study demonstrates a strict temporal requirement for a virulence determinant of the Lyme disease spirochete Borrelia burgdorferi during a unique point in its natural infection cycle, which alternates between ticks and small mammals. OspC is a major surface protein produced by B. burgdorferi when infected ticks feed but whose synthesis decreases after transmission to a mammalian host. We have previously shown that spirochetes lacking OspC are competent to replicate in and migrate to the… CONTINUE READING
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