Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells.

@article{Sharma2015BorreliaBT,
  title={Borrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister Cells.},
  author={Bijaya Sharma and Autumn V Brown and Nicole E Matluck and Linden T Hu and Kim Lewis},
  journal={Antimicrobial agents and chemotherapy},
  year={2015},
  volume={59 8},
  pages={4616-24}
}
Borrelia burgdorferi is the causative agent of Lyme disease, which affects an estimated 300,000 people annually in the United States. When treated early, the disease usually resolves, but when left untreated, it can result in symptoms such as arthritis and encephalopathy. Treatment of the late-stage disease may require multiple courses of antibiotic therapy. Given that antibiotic resistance has not been observed for B. burgdorferi, the reason for the recalcitrance of late-stage disease to… CONTINUE READING