Boron neutron capture therapy of brain tumors: biodistribution, pharmacokinetics, and radiation dosimetry sodium borocaptate in patients with gliomas.

@article{Goodman2000BoronNC,
  title={Boron neutron capture therapy of brain tumors: biodistribution, pharmacokinetics, and radiation dosimetry sodium borocaptate in patients with gliomas.},
  author={Joseph H. Goodman and Weilian Yang and Rolf Barth and Z Gao and Carl P. Boesel and Alfred E. Staubus and Nalin Gupta and Reinhard A. Gahbauer and Danielle M Adams and Christopher R. Gibson and Amy K. Ferketich and Melvin L. Moeschberger and Albert H. Soloway and D. E. O. S. Carpenter and Brent J Albertson and William F Bauer and Ming Zhang and Chung C. Wang},
  journal={Neurosurgery},
  year={2000},
  volume={47 3},
  pages={608-21; discussion 621-2}
}
OBJECTIVE The purpose of this study was to obtain tumor and normal brain tissue biodistribution data and pharmacokinetic profiles for sodium borocaptate (Na2B12H11SH) (BSH), a drug that has been used clinically in Europe and Japan for boron neutron capture therapy of brain tumors. The study was performed with a group of 25 patients who had preoperative diagnoses of either glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA) and were candidates for debulking surgery. Nineteen of these… CONTINUE READING

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