Boron neutron capture therapy for undifferentiated thyroid carcinoma: preliminary results with the combined use of BPA and BOPP.

@article{Viaggi2004BoronNC,
  title={Boron neutron capture therapy for undifferentiated thyroid carcinoma: preliminary results with the combined use of BPA and BOPP.},
  author={Mabel Viaggi and Maria Alejandra Dagrosa and Juan M Longhino and Herman Blaumann and Osvaldo Calzetta and Stephen B. Kahl and Guillermo Juan Juvenal and Mario Alberto Pisarev},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={2004},
  volume={61 5},
  pages={
          905-9
        }
}
We have shown the selective uptake of borophenylalanine (BPA) by undifferentiated human thyroid cancer (UTC) ARO cells both in vitro and in vivo. Moreover, a 50% histologic cure of mice bearing the tumor was observed when the complete boron neutron capture therapy was applied. More recently we have analyzed the biodistribution of BOPP (tetrakis-carborane carboxylate ester of 2,4-bis-(alpha,beta-dihydroxyethyl)-deutero-porphyrin IX) and showed that when BOPP was injected 5 days before BPA, and… CONTINUE READING
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