Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors.

@article{Wu2013BornaDV,
  title={Borna disease virus-induced neuronal degeneration dependent on host genetic background and prevented by soluble factors.},
  author={Yuan-Ju Wu and Herbert Schulz and Chia-Ching Lin and Kathrin Saar and Giannino Patone and Heike Fischer and Norbert H{\"u}bner and Bernd Heimrich and Martin Schwemmle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 5},
  pages={1899-904}
}
Infection of newborn rats with Borne disease virus (BDV) results in selective degeneration of granule cell neurons of the dentate gyrus (DG). To study cellular countermechanisms that might prevent this pathology, we screened for rat strains resistant to this BDV-induced neuronal degeneration. To this end, we infected hippocampal slice cultures of different rat strains with BDV and analyzed for the preservation of the DG. Whereas infected cultures of five rat strains, including Lewis (LEW) rats… CONTINUE READING

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