Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis

@article{Rackov2010BornaDV,
  title={Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis},
  author={Sylva Rackov{\'a} and L. Janu and Hana Kab{\'i}{\vc}kov{\'a}},
  journal={BMC Psychiatry},
  year={2010},
  volume={10},
  pages={70 - 70}
}
BackgroundBorna disease virus (BDV) is an RNA virus belonging to the family Bornaviridae. Borna disease virus is a neurotropic virus that causes changes in mood, behaviour and cognition. BDV causes persistent infection of the central nervous system. Immune changes lead to activation of infection. Alcohol and drug dependence are associated with immune impairment.MethodsWe examined the seropositivity of BDV circulating immunocomplexes (CIC) in patients with alcohol and drug dependence and healthy… Expand
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A significantly higher prevalence of CIC, indicating a chronic BDV infection, in patients with treated primary psychosis than in blood donor controls is found, thus supporting similar global trends for other mental disorders. Expand
Reverse Transcription PCR Assays for Detection of Borna Disease Virus in Psychiatric Patients
Borna disease virus (BDV) is a virus that naturally infects the central nervous system (CNS) of broad range of warm-blooded animals. BDV is an enveloped virus, nonsegmented, negativestranded RNAExpand
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Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder
TLDR
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TLDR
A double-blind placebo-controlled randomized clinical trial (RCT) which cross-linked depression and BDV-1 infection, addressing both the antidepressant and antiviral efficacy of amantadine indicates profound antidepressant efficacy of safe oral amanadine treatment, paralleling antiviral effects at various infection levels. Expand
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TLDR
Evidence is provided that BDV infection among healthy domestic animal species is more widespread in western China than previously believed. Expand
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1.1 Psychiatric disorders and infectious diseases Psychiatric disorders are a wide group of diseases with a heterogeneous aetiology (genetic predisposition, environmental factors, exposure to stress,Expand
Obesity induced by Borna disease virus in rats: key roles of hypothalamic fast-acting neurotransmitters and inflammatory infiltrates
TLDR
Clear evidence is provided that BDV-1 induced obesity in the rat model is the result of interdependent structural and functional metabolic changes, which can be explained by an immunologically induced hypothalamic microcirculation-defect, combined with a disturbance of neurotransmitter regulatory systems. Expand
Full‐length genomic sequencing and characterization of Borna disease virus 1 isolates: Lessons in epidemiology
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Borna disease virus - fact and fantasy.
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The history, molecular biology, epidemiology, and pathobiology of bornaviruses is reviewed. Expand
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The highest levels of BDV CIC were detected in patients with more severe psychopathology, and this was associated with the higher severity of psychopathology in comparison with patients with mild or moderate psychopathology. Expand
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TLDR
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