Borna disease, a possible hazard for man?

@article{Rott2005BornaDA,
  title={Borna disease, a possible hazard for man?},
  author={Rudolf Rott and Sibylle Herzog and Karl Bechter and Knut Frese},
  journal={Archives of Virology},
  year={2005},
  volume={118},
  pages={143-149}
}
SummaryEvidence is presented that Borna disease (BD) virus, which is known to cause encephalopathy in horses, sheep, and a broad range of experimental animals, or a related agent, can infect man and may induce mental disorders. BD virus-specific antibodies could be demonstrated in 4–7% of sera (depending on origin) from more than 5000 psychiatric or neurological patients from Germany, U.S.A. and Japan. Antibodies from seropositive patients reacted with a BD virus-specific protein translated by… 
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Borna disease virus and the evidence for human pathogenicity: a systematic review.
TLDR
There is evidence that humans are exposed to the Borna Disease virus, and agreed gold standard tests and evidence for test specificity are lacking, but further epidemiological studies are required to establish whether there are associations with disease.
Borna Disease Virus RNA in Immunocompromised Patients in Southwestern France
TLDR
The severity and particularity of cellular immunosuppression could explain the significantly increased detection of BDV RNA in HIV-infected patients.
Natural Infection and Transmission Animal Models for Bdv Pathogenesis Borna Disease
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BDV replicates at lower levels than most known viruses, is not lytic, and persists in the nervous system despite a vigorous immune response, suggesting that the virus may be even more widespread than previously thought.
Borna disease virus
TLDR
Analysis of rodent models of infection has yielded insights into mechanisms by which neurotropic agents and/or immune factors may impact developing or mature central nervous system circuitry to effect complex disturbances in movement and behavior.
Role of Borna disease virus in neuropsychiatric illnesses: are we inching closer?
TLDR
The current state of knowledge and recent advances in diagnosis are analyzed in order to prove or refute the association of Borna disease virus in causation of human neuropsychiatric disorders.
The diagnosis of proventricular dilatation disease: use of a Western blot assay to detect antibodies against avian Borna virus.
Demonstration of Borna disease virus-specific RNA in secretions of naturally infected horses by the polymerase chain reaction
The presence of Borna disease virus (BDV)-specific RNA was traced by the reverse transcriptase-polymerase chain reaction in conjunctival fluid, nasal secretions and saliva of horses which were…
Borna disease virus - fact and fantasy.
Prevalence of Borna disease virus RNA in peripheral blood mononuclear cells from blood donors
TLDR
The results suggest that BDV infection in humans may be more widespread than previously thought.
No evidence of Borna disease virus-specific antibodies in multiple sclerosis patients in Germany
TLDR
1. report of three cases, including one observed over 43 years, and computed tomographic findings, of brain involvement in progressive facial hemiatrophy (Romberg disease): reconsideration of a syndrome.
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References

SHOWING 1-10 OF 33 REFERENCES
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TLDR
Antibodies to the virus were demonstrated in 16 of the patients but none of the normal volunteers, and patients with the positive serum samples were characterized by having histories of affective disorders, particularly of a cyclic nature.
Borna disease virus. A possible etiologic factor in human affective disorders?
TLDR
It will be necessary to replicate and extend these intriguing preliminary results to determine if Borna disease virus is possibly involved in the pathogenesis of affective disorders in humans.
Isolation and characterization of Borna disease agent cDNA clones.
TLDR
In situ hybridization experiments using RNA probes prepared from cDNA clones from a rat with Borna disease indicated that the BD agent is probably a virus with major transcripts of 8.5, 2.1, and 0.8 kilobases.
The cerebrospinal fluid of rabbits infected with Borna disease virus
TLDR
The results suggest that antibodies detected in the CSF are locally produced, and the significance of these findings for the pathogenesis of Borna disease is discussed.
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TLDR
These studies showed that BDV has the physical and replicative properties typical of conventional viruses but its mechanism of replication and site of morphogenesis may be unique.
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TLDR
The hypothesis that unresponsiveness and even tolerance can be induced by CSA in the presence of the foreign Ag is supported, demonstrating the beneficial effect of this immunosuppressive drug during a persistent viral infection.
Effect of Borna disease virus infection on athymic rats.
TLDR
The results obtained confirm the previous concept that the genesis of Borna disease, at least in rats, is attributed to a cellular immune response.
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TLDR
The frenzied behavior and subsequent blindness in immunocompetent adults were attributed to a uniquely transient immunopathologic reaction targeted to centers in the limbic system and retinal neurons.
Borna disease of horses
TLDR
The brains of eight horses that had suffered from natural Borna disease were examined with virologic, immunohistological, and electron-microscopic methods, yielding pathologic alterations very similar to those of the classical description of the disease.
Pathogenesis of Borna disease in rats: evidence that intra-axonal spread is the major route for virus dissemination and the determinant for disease incubation
TLDR
The incubation period is the time required for transport of the agent in dendritic-axonal processes from the site of inoculation to the hippocampus and the exclusiveness of the neural conduit was proven by failure to cause infection after injection of the virus intravenously or into the feet of neurectomized rats.
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