Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?

  title={Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?},
  author={Sylva Rackov{\'a} and L. Janu},
1.1 Psychiatric disorders and infectious diseases Psychiatric disorders are a wide group of diseases with a heterogeneous aetiology (genetic predisposition, environmental factors, exposure to stress, for example). Several infectious agents preferentially affect the central nervous system and these infections are associated with psychic and neurologic symptomatology. It has been suggested that some infectious diseases can influence the development and the course of several psychiatric disorders… Expand
3 Citations
The role of viruses in neurodegenerative and neurobehavioral diseases.
The main focus of this review is to illustrate the association between viral infections and both neurodegenerative and neurobehavioral diseases, so that the possible mechanism and pathway of neuro degenerative diseases can be better explained. Expand
Molecular Detection of Borna Disease Virus in Patients with Schizophrenia in Mazandaran Province
This study supports previous findings regarding the relationship between BDV and psychiatric disorders, especially schizophrenia and suggests this virus could be considered as an environmental factor that can increase the risk of mental illnesses in adults. Expand
An association of virus infection with type 2 diabetes and Alzheimer's disease.
The association of few common viruses like Hepatitis C Virus and Herpes Simplex Virus-1 which affects both diabetes and AD and the pathological links of Influenza virus, Cytomegalovirus, West Nile virus, Enterovirus and Borna disease virus in AD are discussed. Expand


Borna disease virus-reactive antibodies and recent-onset psychiatric disorders
The association between Borna disease virus (BDV) and psychiatric disorders remains controversial. In animals, manifestations of infections with BDV show some resemblance to psychopathologicalExpand
Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients
There is a lack of association between BDV and HTLV-1 infections with psychiatric disorders among Japanese patients, and this is the first isolated human retrovirus that causes adult T-cell leukemia with neurological symptoms. Expand
Borna Disease Virus and the Brain
Borna disease virus (BDV) provides an important model for the investigation of the mechanisms and consequences of viral persistence in the CNS that can lead to neurodevelopmental abnormalities, immune-mediated damage, as well as alterations in cell differentiated functions that affect brain homeostasis. Expand
Borna disease virus infection and affective disorders in man.
The first data of a current follow-up study on 70 psychiatric patients who were tested three times each after hospitalization found 20% positives by follow- up testing, leading to hypothesize that Bornavirus infection might contribute somehow to the syndrome of major depressive illness by altering neuronal cells in the limbic system. Expand
Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders.
The results indicate that life-long persistent BDV infections are rare in humans and that such infections may be associated with certain forms of hippocampal degeneration. Expand
Borna disease virus infection in Italian children. A potential risk for the developing brain?
The goal of this work was to monitor the prevalence of BDV infection among Italian children, which was unexplored worldwide except for unpublished information by Shollbach and Bode. Expand
RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives
Investigation of p24 RNA from Borna disease virus (BDV) by the reverse transcriptase polymerase chain reaction in patients with schizophrenia, schizoaffective disorder, and in their biological relatives found no significant differences, however, the clinical significance of BDV remains to be clarified. Expand
A viro-psycho-immunological disease-model of a subtype affective disorder.
It is hypothesized that humanBDV infection represents a co-factor in the development or course of psychiatric diseases, and the possible interactions between stress-induced immunosuppression, BDV infection and affective disorders in humans are discussed. Expand
Role of Borna disease virus in neuropsychiatric illnesses: are we inching closer?
The current state of knowledge and recent advances in diagnosis are analyzed in order to prove or refute the association of Borna disease virus in causation of human neuropsychiatric disorders. Expand
Activated Borna disease virus in affective disorders.
The high rate of BDVAG, especially in fatigued patients with recurrent major depression or bipolar disorder, may be a nonspecific aspect of immunosuppression. Expand