Borna Disease Virus (BDV) infection in cats a concise review based on current knowledge

  title={Borna Disease Virus (BDV) infection in cats a concise review based on current knowledge},
  author={S Kamhieh and R. L. P. Flower},
  journal={Veterinary Quarterly},
  pages={65 - 73}
Summary Persistent viral infections of the central nervous system have been the subject of intense interest for decades. One of these viral agents has been identified as Borna disease virus (BDV) of the family Bornaviridae. There have been various reports that link BDV to staggering disease in cats, with symptoms that include ataxia and behavioural disorders, and the disease is often referred to as feline Borna disease. Serological and molecular detection of BDV has been reported at a higher… 
Interferon expression in feline Borna disease
Investigating whether the gene expression, measured by quantitative RT-PCR, of IFN-α, -β and -γ in the brain tissues of Borna disease diagnosed cats is induced showed clear association betweenBorna disease diagnosis and increasedIFN-γ gene expression.
Borna disease virus and its host
Three studies suggest that serology is the most useful tool to further strengthen a clinical suspicion of feline BD, whereas molecular diagnostics, using blood samples, can be added for cats showing mild neurological signs, and that more direct effects of BDV in disease development than has previously been considered.
Serological evidence for Borna Disease Virus infection in children, cats and horses in Sicily (Italy)
To contribute to a possible zoonotic transmission from domestic animals to man, the human and animal prevalence of BDV infection in the same area is studied.
Serological evidence for Borna disease virus infection in humans, wild rodents and other vertebrates in Finland.
Staggering disease in cats in Sweden : Development of molecular methods for detection and genetic characterization of Borna disease virus strains
Some of the problems of studying RNA viruses present in small amounts in brain tissue are identified and there is always a risk that the RNA is lost during the RNA extraction process, so further studies are needed to provide more information about the BDV molecular epidemiology in Sweden.
CNS Disease in the Cat: Current Knowledge of Infectious Causes
PLA som metod för detektion av bornavirusinfektion hos katt
The aim of this work was to explore the possibility of using the proximity ligation assay (PLA), with its capacity of recognizing femtomolar con-centrations of a protein, as a method for detection of the minute quantities of antigen and antibodies that are present in the tissues and body fluids of a bornaviraly infected cat.
The following are some of the main themes that have emerged since the publication of the first collection of letters to the editor:.
Tollwut und Bornavirus-Enzephalitis
A severe, often fatal encephalitis needs to be extensively and carefully clarified, especially when it occurs in a patient weeks or months after an organ transplantation, because patients carry a high risk of infection for all caregivers.
Infectious Diseases


Natural Borna disease virus infection in cats in the United Kingdom
In a serosurvey of 111 cats the incidence of antibody to BDV in Cats with neurological disease was higher than in cats with other types of disease, suggesting that the virus may play a role in nervous diseases of cats in the UK.
Borna disease virus (BDV), a (zoonotic?) worldwide pathogen. A review of the history of the disease and the virus infection with comprehensive bibliography.
  • R. Dürrwald, H. Ludwig
  • Biology
    Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B
  • 1997
BDV, the prototype of the family Bornaviridae is an enveloped spherical virus carrying an 8.9 kb single-stranded, non-segmented RNA with negative polarity which replicates in the nucleus which makes this non-cytopathogenic virus an evolutionary 'old pathogen' in nature.
Borna disease virus: new aspects on infection, disease, diagnosis and epidemiology.
The association with psychiatric diseases in humans led to an international explosion of research on Borna disease virus, with centres established in Germany, the United States of America and Japan.
Borna disease virus infection in animals and humans.
Seroepidemiologic and cerebrospinal fluid investigations of psychiatric patients suggest a causal role of BDV infection in human psychiatric disorders, and in diagnostically unselected psychiatric patients, the distribution of psychiatric disorders was found to be similar in BDV seropositive and seronegative patients.
Borna disease virus infection in domestic cats: evaluation by RNA and antibody detection.
There are neurologically asymptomatic domestic cats infected with BDV present in the Tokyo area, both by the presence of plasma antibodies against BDV-p24 and -p40 and by RNA detection in peripheral blood mononuclear cells.
No evidence of endemic Borna disease virus infection in Australian horses in contrast with endemic infection in other continents
A very low frequency of serological markers that may be associated with exposure to BDV in Australian horses from NSW with a few sera displaying low range positive results in the CIC assay, and no detectable BDV RNA is revealed.
Borna disease virus infection in racing horses with behavioral and movement disorders
The results point to an association of BDV infection with atypical disease patterns in horses such as diffuse mental and gait disturbances, and may be of importance for the understanding of the epidemiology ofBDV infections in animals and man.
Staggering disease in cats: isolation and characterization of the feline Borna disease virus.
Using the brain suspension of a newborn rat inoculated with feline brain tissue material, it was possible to induce typical Borna disease (BD) in four adult rats, indicating a possible adaptation of the cat virus during passages in rats.
Isolation and Characterization of a New Subtype of Borna Disease Virus
The data indicate that the genome of BDV is far more variable than previously assumed and that naturally occurring subtypes may escape detection by currently used diagnostic assays.