Born to run: control of transcription elongation by RNA polymerase II

@article{Chen2018BornTR,
  title={Born to run: control of transcription elongation by RNA polymerase II},
  author={F. X. Chen and Edwin R. Smith and A. Shilatifard},
  journal={Nature Reviews Molecular Cell Biology},
  year={2018},
  volume={19},
  pages={464-478}
}
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an integral part of the implementation of gene expression programmes during development. In most metazoans, the majority of transcribed genes exhibit transient pausing of Pol II at promoter-proximal regions, and the release of Pol II into gene bodies is controlled by many regulatory factors that respond to environmental and developmental cues. Misregulation of the elongation stage of transcription is implicated… Expand
The DNA damage response to transcription stress
Organization and regulation of gene transcription
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