Corpus ID: 54082006

Boric acid inhibits cell growth and induces apoptosis in breast cancer cells

  title={Boric acid inhibits cell growth and induces apoptosis in breast cancer cells},
  author={Anu Elegbede},
Boric Acid Inhibits Cell Growth and Induces Apoptosis in Breast Cancer Cells by Anuoluwapo Funmilola Elegbede Dr. Stephen W. Carper, Examination Committee Chair Professor o f Biochemistry University o f Nevada, Las Vegas Boric acid (BA), an essential plant micronutrient, has recently been discovered as a chemo-preventive agent in prostate cancer; however, its mechanism of action remains unknown. Our interest is to determine if BA has a preventative role in breast cancer and elucidate its… Expand
A Study on the Anticarcinogenic Effects of Calcium Fructoborate
The results imply that CaFB may have therapeutic potential as well as preventive benefits in cancer. Expand
Update on human health effects of boron.
  • F. Nielsen
  • Chemistry, Medicine
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2014
Increasing boron intake by consuming a diet rich in fruits, vegetables, nuts and pulses should be recognized as a reasonable dietary recommendation to enhance health and well-being. Expand
Growing Evidence for Human Health Benefits of Boron
A low boron intake should be considered a health concern, which can be prevented by diets rich in fruits, vegetables, nuts, and pulses. Expand
Effect of Boric Acid Supplementation on the Expression of BDNF in African Ostrich Chick Brain
Results indicated that appropriate supplementation of boric acid, especially at 160 mg/L, could promote ostrich chicks’ brain development by promoting the BDNF expression and reducing cell apoptosis, and high dose of bric acid would damage the neuron structure of ostrich chick brain. Expand


Boron Supplementation Inhibits the Growth and Local Expression of IGF-1 in Human Prostate Adenocarcinoma (LNCaP) Tumors in Nude Mice
Low-level dietary boron supplementation reduced tumor size and content of a tumor trophic factor, IGF-1, in an animal model using nude mice implanted subcutaneously with LNCaP cells in Matrigel. Expand
Signalling via integrins: implications for cell survival and anticancer strategies.
Issues as well as a variety of therapeutic options envisioned to influence tumour cell growth, metastasis and resistance, including kinase inhibitors, anti-integrin antibodies or RNA interference, will be summarized and discussed in this review. Expand
Integrins in invasive growth.
How integrins affect migration, proliferation, and survival of both transformed and normal cells are described, and how they modulate invasive growth in vivo is discussed. Expand
Boron Modulates Extracellular Matrix and TNFα Synthesis in Human Fibroblasts
The effects of boric acid observed in wound repairin vivomay be due to TNFα synthesis and secretion. Expand
Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
Increased groundwater boron concentrations, across the state of Texas, correlate with reduced risk of prostate cancer incidence and mortality, and boric acid improves the anti-proliferative effectiveness of chemo-preventative agents, selenomethionine and genistein, while enhancing ionizing radiation cell kill. Expand
Environmental pollutants, diet, physical activity, body size, and breast cancer
Evidence is emerging for associations between breast cancer and polychlorinated biphenyls, polycyclic aromatic hydrocarbons, and organic solvents and improved exposure assessment methods will help advance future human studies of both diet and environmental pollutants. Expand
Vegetables, fruit, and cancer. I. Epidemiology
The epidemiologic literature on the relationship between vegetable and fruit consumption and human cancer at a variety of sites is reviewed systematically and it is concluded that consumption of higher levels of vegetables and fruit is associated consistently, although not universally, with a reduced risk of cancer at most sites. Expand
Tissue transglutaminase: an enzyme with a split personality.
  • J. Chen, K. Mehta
  • Biology, Medicine
  • The international journal of biochemistry & cell biology
  • 1999
The ability of tTG to mediate signal transduction may contribute to its involvement in the regulation of cell cycle progression and the following features of this multifunctional enzyme that have emerged as a result of recent work from different laboratories are summarized. Expand
Arabidopsis boron transporter for xylem loading
It is shown here that BOR1 is an efflux-type boron transporter for xylem loading and is essential for protecting shoots from borons deficiency. Expand
n‐Alkylboronic acids as bifunctional reversible inhibitors of α‐chymotrypsin
Study of the interaction of enzymes with polyfunctional reversible inhibitors may yield valuable information on the spatial arrangement of the active site. Earlier [l] we proposed the use ofExpand