Bordetella type III secretion modulates dendritic cell migration resulting in immunosuppression and bacterial persistence.

@article{Skinner2005BordetellaTI,
  title={Bordetella type III secretion modulates dendritic cell migration resulting in immunosuppression and bacterial persistence.},
  author={Jason Skinner and Mylisa Pilione and Hao Shen and Eric T. Harvill and Ming H. Yuk},
  journal={Journal of immunology},
  year={2005},
  volume={175 7},
  pages={
          4647-52
        }
}
Chronic bacterial infection reflects a balance between the host immune response and bacterial factors that promote colonization and immune evasion. Bordetella bronchiseptica uses a type III secretion system (TTSS) to persist in the lower respiratory tract of mice. We hypothesize that colonization is facilitated by bacteria-driven modulation of dendritic cells (DCs), which leads to an immunosuppressive adaptive host response. Migration of DCs to the draining lymph nodes of the respiratory tract… CONTINUE READING
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