Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells.

@article{Ryan1997BordetellaPR,
  title={Bordetella pertussis respiratory infection in children is associated with preferential activation of type 1 T helper cells.},
  author={Marianne Ryan and George W. Murphy and Leif Gothefors and Lennart Nilsson and Jann Storsaeter and Kingston H. G. Mills},
  journal={The Journal of infectious diseases},
  year={1997},
  volume={175 5},
  pages={1246-50}
}
The mechanism of protective immunity against Bordetella pertussis generated following recovery from whooping cough in childhood has not yet been elucidated. Studies with a murine respiratory infection model have indicated that cellular immunity, mediated by Th1 cells, plays a role in the clearance of a primary infection with B. pertussis and in protection against subsequent challenge. In the present study, the induction of B. pertussis-specific Th cell subsets in children was examined… CONTINUE READING
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