Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.

@article{Spensieri2006BordetellaPI,
  title={Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP induction.},
  author={Fabiana Spensieri and Giorgio Fedele and C. Victor W. Fazio and Maria Nasso and Paola Stefanelli and Paola Mastrantonio and Clara Maria Ausiello},
  journal={Infection and immunity},
  year={2006},
  volume={74 5},
  pages={2831-8}
}
Bordetella pertussis, the causative agent of whooping cough, possesses an array of virulence factors, including adenylate cyclase toxin (ACT), relevant in the establishment of infection. Here we better define the impact of cyclic AMP (cAMP) intoxication due to the action of ACT on dendritic cell (DC)-driven immune response, by infecting monocyte-derived DC (MDDC) with an ACT-deficient B. pertussis mutant (ACT- 18HS19) or its parental strain (WT18323). Both strains induced MDDC maturation and… CONTINUE READING
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