Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes

@article{Boulanger2015BordetellaPF,
  title={Bordetella pertussis fim3 gene regulation by BvgA: Phosphorylation controls the formation of inactive vs. active transcription complexes},
  author={Alice Boulanger and Kyung Ho Moon and Kimberly Baxter Decker and Qing Ching Chen and Leslie Knipling and Scott E. Stibitz and Deborah M. Hinton},
  journal={Proceedings of the National Academy of Sciences},
  year={2015},
  volume={112},
  pages={E526 - E535}
}
Significance The response regulator BvgA controls virulence gene expression in the human pathogen Bordetella pertussis. Phosphorylated BvgA together with RNA polymerase form transcription complexes that synthesize RNA from the B. pertussis promoter for the fimbrial gene fim3. We show that nonphosphorylated BvgA and RNA polymerase form stable but inactive complexes. We propose that these complexes may modulate fim3 expression under inducing conditions and facilitate rapid repression of the fim3… Expand
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