Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin.

@article{Berggrd1997BordetellaPB,
  title={Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin.},
  author={Karin Bergg{\aa}rd and Eskil Johnsson and Frits R. Mooi and Gunnar Lindahl},
  journal={Infection and immunity},
  year={1997},
  volume={65 9},
  pages={3638-43}
}
C4BP (C4b-binding protein) is a high-molecular-weight plasma protein that inhibits the classical pathway of complement activation. Recent experiments have demonstrated that C4BP binds to many strains of the gram-positive bacterium Streptococcus pyogenes, a major respiratory tract pathogen. Binding to S. pyogenes was shown to be due to members of the M protein family, a group of surface proteins important for virulence. Here we report that human C4BP also binds to all clinical isolates of the… CONTINUE READING

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Genes for the filamentous hemagglutinin and fimbriae of Bordetella pertussis: colocation, coregulation and cooperation

  • F. R. Mooi
  • Molecular genetics of bacterial pathogenesis
  • 1994
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