Borderline personality disorder and childhood maltreatment: A genome-wide methylation analysis

@article{Stenz2016BorderlinePD,
  title={Borderline personality disorder and childhood maltreatment: A genome-wide methylation analysis},
  author={Ludwig Stenz and Julien Prados and Philippe Courtet and Paco Prada and Rosetta Nicastro and Wafae Adouan and S{\'e}bastien Guillaume and Emilie Olié and Jean-Michel Aubry and Alexandre G Dayer and Nader Perroud},
  journal={European Psychiatry},
  year={2016},
  volume={33},
  pages={S183 - S183}
}
Early life adversity plays a critical role in the emergence of borderline personality disorder (BPD) and this could occur through epigenetic programming. In this perspective, we aimed to determine whether childhood maltreatment could durably modify epigenetic processes by the means of a whole-genome methylation scan of BPD subjects. Using the Illumina Infinium® Human Methylation 450 Bead Chip, global methylation status of DNA extracted from peripheral blood leucocytes was correlated to the… Expand
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