Borderline personality disorder and childhood maltreatment: A genome-wide methylation analysis

  title={Borderline personality disorder and childhood maltreatment: A genome-wide methylation analysis},
  author={Ludwig Stenz and Julien Prados and Philippe Courtet and Paco Prada and Rosetta Nicastro and Wafae Adouan and S{\'e}bastien Guillaume and Emilie Olié and Jean-Michel Aubry and Alexandre G Dayer and Nader Perroud},
  journal={European Psychiatry},
  pages={S183 - S183}
Early life adversity plays a critical role in the emergence of borderline personality disorder (BPD) and this could occur through epigenetic programming. In this perspective, we aimed to determine whether childhood maltreatment could durably modify epigenetic processes by the means of a whole-genome methylation scan of BPD subjects. Using the Illumina Infinium® Human Methylation 450 Bead Chip, global methylation status of DNA extracted from peripheral blood leucocytes was correlated to the… Expand
Aberrant DNA Methylation of rDNA and PRIMA 1 in Borderline Personality Disorder
Borderline personality disorder (BPD) is a serious psychic disease with a high risk for suicide. DNA methylation is a hallmark for aberrant epigenetic regulation and could be involved in the etiologyExpand
Epigenome-wide associations between observed maternal sensitivity and offspring DNA methylation: a population-based prospective study in children.
These findings provide novel leads into the relationship between typical variation in maternal caregiving and offspring DNAm in humans, highlighting robust regions of associations, previously implicated in psychological and developmental problems, immune functioning, and stress responses. Expand
Epigenetic & transcriptomic alterations associated with childhood maltreatment, major depressive disorder, and post-traumatic stress disorder
To gain a deeper understanding of the relationship between childhood maltreatment and the biologic mechanisms contributing to it, it is necessary to first understand the impact of each exposure on different biologic systems and processes. Expand
Investigating epigenetic consequences of early-life adversity: some methodological considerations
Issues regarding sample characteristics in epigenetic studies of early life adversity are identified and methods and technologies used for candidate gene analysis and whole epigenome studies are compared. Expand
Neurodevelopmental plasticity and psychiatric vulnerability
Investigating the role of the ionotropic serotonin 3A receptor at a genetic and epigenetic level in rodent and human models of early-life stress found that ELS interacts with the 5-HTR3A to modulate social behaviors and childhood adversity significantly impacts the methylation status of the promoter region of the human 5-HT3AR in an allele-specific manner. Expand
The aetiology of borderline personality disorder (BPD): contemporary theories and putative mechanisms.
  • C. Winsper
  • Psychology, Medicine
  • Current opinion in psychology
  • 2018
An overview of current knowledge regarding the aetiology of Borderline Personality Disorder is presented, including a brief synopsis of early research and theory, and how changing conceptualisations of BPD have impacted on aetiological knowledge is discussed. Expand
Traumatic Stress Epigenetics
Moving forward, increasing focus on epigenetic marks of traumatic stress in CNS tissue will create a clearer picture of the relevance of peripheral measures, and leveraging multigenerational birth cohort data will do much to clarify the extent of transgenerational epigenetic effects oftraumatic stress. Expand
The significance of microRNAs in the course of rDD.
There is no significant difference in miRNAs expression between patients with recurrent depressive disorders and those in the first episode of depression. Expand
Looking back and moving forward: Evaluating and advancing translation from animal models to human studies of early life stress and DNA methylation
A classification scheme to systematically evaluate the match between characteristics of human and animal studies of ELS and DNA methylation is provided and immediate and longer-term suggestions to improve translational specificity are offered. Expand
Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation.
  • J. Blaze, T. Roth
  • Biology, Medicine
  • Seminars in cell & developmental biology
  • 2015
Clinical research and work from animal models that provide evidence of the impact of stressful experiences either during the perinatal period or adulthood on DNA methylation and behavior are highlighted and the more controversial concept of transgenerational inheritance is explored. Expand