Borderline personality disorder

@article{Lieb2004BorderlinePD,
  title={Borderline personality disorder},
  author={Klaus Lieb and Mary C. Zanarini and Christian Schmahl and Marsha M. Linehan and Martin Bohus},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={453-461}
}
Tryptophan Hydroxylase-1 Gene Variants Associate with a Group of Suicidal Borderline Women
TLDR
The data support the expectation that haplotype analysis is superior to single locus analysis in gene–disease, case–control association studies and conclude that TPH-1 associates with BPD in suicidal women. Expand
Significant grey matter changes in a region of the orbitofrontal cortex in healthy participants predicts emotional dysregulation.
The traditional concept of 'categorical' psychiatric disorders has been challenged as many of the symptoms display a continuous distribution in the general population. We suggest that this is theExpand
Preliminary Investigation of the Psychometric Properties of the Parent Version of the Borderline Personality Features Scale for Children (BPFS-P)
TLDR
Examination of the psychometric properties of the parent version of the Borderline Personality Features Scale for Children points to the potential of the BPFS-P to break new ground in identifying youth at risk for BPD. Expand
Borderline personality disorder and emotion dysregulation
  • A. Chapman
  • Medicine, Psychology
  • Development and Psychopathology
  • 2019
TLDR
Prevention and treatment efforts hold great promise for reducing the long-term suffering, functional impairment, and considerable societal costs associated with BPD. Expand
Psychopathological outcomes of adolescent borderline personality disorder symptoms
TLDR
Adolescents with borderline personality disorder symptoms are at future risk of psychotic and hypomanic symptoms, and a diagnosis of depression, indicating that adolescent borderline Personality disorder symptoms have multifinal outcomes. Expand
Benchmarks for Outpatient Dialectical Behavioral Therapy in Adults With Borderline Personality Disorder
Purpose: This article provides benchmark data on within-group effect sizes from published randomized clinical trials supporting the efficacy of dialectical behavioral therapy (DBT) for borderlineExpand
Morphological connectivity correlates with trait impulsivity in healthy adults
TLDR
Evidence is provided that the ACC, IFG, and ITG in the right hemisphere are involved neural networks modulating impulsivity, and the utility of MC analyses in facilitating the understanding of neural correlates of behavioral and personality traits is highlighted. Expand
Systems Training for Emotional Predictability and Problem Solving Program and Emotion Dysregulation: A Pilot Study
TLDR
STEPPS is associated with an improvement in emotion regulation and a reduction in the number of hospitalizations and suicide attempts and seems to act on the behavioral dimensions of emotion dysregulation like the ability to control impulsive behaviors and to achieve goals. Expand
Borderline and cluster C personality disorders manifest distinct physiological responses to psychosocial stress
TLDR
It is indicated that patients with BPD have significant alterations in their physiological stress reactivity, which is notably distinct from patients with CPD and those of healthy controls. Expand
Brain structural anomalies in borderline and avoidant personality disorder patients and their associations with disorder-specific symptoms.
TLDR
These results shed light on potentially protective, or compensatory, aspects of brain structure in these populations-namely, relatively reduced amygdala volume or relatively enhanced MPFC and DLPFC volume. Expand
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References

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A positron emission tomography study of memories of childhood abuse in borderline personality disorder
TLDR
Dysfunction of dorsolateral and medial prefrontal cortex, including anterior cingulate, seems to be correlated with the recall of traumatic memories in women with BPD. Expand
Effectiveness of inpatient dialectical behavioral therapy for borderline personality disorder: a controlled trial.
TLDR
The data suggest that three months of inpatient DBT treatment is significantly superior to non-specific outpatient treatment within a relatively short time frame, and improvement was found across a broad range of psychopathological features. Expand
Mental health service utilization by borderline personality disorder patients and Axis II comparison subjects followed prospectively for 6 years.
TLDR
The results of this study suggest that the majority of borderline patients continue to use outpatient treatment in a sustained manner through 6 years of follow-up, but only a declining minority use more restrictive and costly forms of treatment. Expand
Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation
TLDR
Pictures of human emotional expressions elicit robust differences in amygdala activation levels in borderline patients, compared with normal control subjects, and can be used as probes to study the neuropathophysiologic basis of borderline personality disorder. Expand
Dialectical behaviour therapy for women with borderline personality disorder
TLDR
Dialectical behaviour therapy resulted in better retention rates and greater reductions of self-mutilating and self-damaging impulsive behaviours compared with usual treatment, especially among those with a history of frequentSelf-mutilation. Expand
Frontolimbic brain abnormalities in patients with borderline personality disorder a volumetric magnetic resonance imaging study
TLDR
Volume loss of a single brain structure like the hippocampus is quite an unspecific finding in neuropsychiatry, but the patterns of volume loss of the amygdala, hippocampus, and left orbitofrontal and right anterior cingulate cortex might differentiate borderline personality disorder from other neuropsychiatric conditions. Expand
Impulsivity and prefrontal hypometabolism in borderline personality disorder
TLDR
FDG-PET studies in 13 non-depressed, impulsive female subjects with BPD and 9 healthy controls to look for abnormalities in glucose metabolism in areas of the PFC associated with regulation of impulsive behavior found significant reductions in FDG uptake. Expand
Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder
TLDR
Gender differences in central serotonergic function may contribute to variations in impulsivity in BPD. Expand
Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder
TLDR
Findings from this study are consistent with the hypothesis that alterations in the hippocampus and amygdala are associated with BPD. Expand
Neural correlates of memories of abandonment in women with and without borderline personality disorder
TLDR
These findings implicate dysfunction of dorsolateral and medial prefrontal cortex including anterior cingulate, left temporal cortex, and visual association cortex in memories of abandonment in women with BPD. Expand
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