Boosting with recombinant vaccinia increases HPV-16 E7-Specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing Sindbis virus replicon particles.

@article{Lin2003BoostingWR,
  title={Boosting with recombinant vaccinia increases HPV-16 E7-Specific T cell precursor frequencies and antitumor effects of HPV-16 E7-expressing Sindbis virus replicon particles.},
  author={Chung-I. Lin and Chien-fu Hung and Jeremy Juang and Liangmei He and Ken-Yu Lin and Tae Woo Kim and T. -C Wu},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2003},
  volume={8 4},
  pages={559-66}
}
Immunotherapy using the heterologous prime-boost regimen has emerged as an attractive approach for generating antigen-specific T-cell-mediated immune responses against tumors and infectious diseases. We have previously linked the Mycobacterium tuberculosis heat-shock protein 70 (HSP70) to the HPV-16 E7 antigen creating a chimera, E7/HSP70. We found that nucleic acid vaccines encoding E7/HSP70 can generate strong antitumor immunity. Recently, replication-defective Sindbis virus replicon particle… CONTINUE READING

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