• Corpus ID: 214611827

Boosting test-efficiency by pooled testing strategies for SARS-CoV-2

  title={Boosting test-efficiency by pooled testing strategies for SARS-CoV-2},
  author={Rudolf Hanel and Stefan Thurner},
  journal={arXiv: Populations and Evolution},
In the current COVID19 crisis many national healthcare systems are confronted with an acute shortage of tests for confirming SARS-CoV-2 infections. For low overall infection levels in the population, pooling of samples can drastically amplify the testing efficiency. Here we present a formula to estimate the optimal pooling size, the efficiency gain (tested persons per test), and the expected upper bound of missed infections in the pooled testing, all as a function of the populationwide… 

Figures from this paper

Implementing Stepped Pooled Testing for Rapid COVID-19 Detection.

A stepped pooled testing strategy, a probability driven approach which significantly reduces the number of tests required to identify infected individuals in a large population and reduces the effective false positive rate of tests when compared to a strategy of testing every individual of a population is introduced.

Effectiveness of Sample Pooling Strategies for SARS-CoV-2 Mass Screening by RT-PCR: A Scoping Review

A cohesive literature review of the effectiveness and accuracy of pooled-sample testing in the detection of SARS-CoV-2 and critically analyze its limitations is compiled.

Nested pool testing strategy for the reliable identification of individuals infected with SARS-CoV-2

An adaptive nested strategy is developed based on Dorfman's algorithm for the identification of individuals infected with SARS-CoV-2 when the infection prevalence is poorly known a priori or when the optimal requires starting with pool sizes that are too large for the reliable detection of an infected sample.

Evaluation of pool-based testing approaches to enable population-wide screening for COVID-19

The results of this study provide a rationale for adoption of pool-based testing strategies to increase speed and throughput of testing for SARS-CoV-2, hence saving time and resources compared with individual testing.

Inflated false-negative rates in pooled RT-PCR tests of SARS-CoV-2

Background : Pooling is a popular strategy for increasing SARS-CoV-2 testing throughput. One popular pooling scheme is Dorfman pooling: test N individuals simultaneously. If the test is positive —

Application of pooled testing in estimating the prevalence of COVID-19

This investigation clarifies some of the issues hotly debated in the context of COVID-19 and shows the potential gains for the Indian Council for Medical Research (ICMR) in using a pooled sampling for their upcoming CO VID-19 prevalence surveys.

Application of pooled testing in screening and estimating the prevalence of Covid-19

The basic statistical theory behind the pooled testing procedure for screening as well as prevalence estimation is explained and theoretical explanation of the impact of diagnostic errors on the performances of individual testing and pooled testing procedures is provided.

Application of Pooled Testing Methodologies in Tackling the COVID-19 Pandemic

This article explores several algorithms for pooling samples to reduce the number of diagnostic tests and discusses the feasibility of using the pooling algorithms and possible avenues to improve their effectiveness.

Multi-Level Group Testing with Application to One-Shot Pooled COVID-19 Tests

This work proposes a multi-level GT scheme, designed specifically to meet the unique requirements of COVID-19 tests, while exploiting the strength of GT theory to enable accurate recovery using much fewer tests than patients.


Aberle, both from the Center for Virology, Medical University of Vienna

  • Private communication on March
  • 2020