Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury

@inproceedings{Zhou2018BoostingMA,
  title={Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-κB pathway quenches intestinal inflammation and oxidative stress injury},
  author={Mingxia Zhou and Weimin Xu and Jiazheng Wang and Junkai Yan and Ying-ying Shi and Cong Zhang and Wensong Ge and Jin Wu and Peng Du and Yingwei Chen},
  booktitle={EBioMedicine},
  year={2018}
}
BACKGROUND AND AIMS Defective autophagy has been proposed as an important event in a growing number of autoimmune and inflammatory diseases such as rheumatoid arthritis and lupus. However, the precise role of mechanistic target of rapamycin (mTOR)-dependent autophagy and its underlying regulatory mechanisms in the intestinal epithelium in response to inflammation and oxidative stress remain poorly understood. METHODS The levels of p-mTOR, LC3B, p62 and autophagy in mice and LPS-treated cells… CONTINUE READING

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Inflammatory Bowel Disease Drugs: A Focus on Autophagy

Journal of Crohn's & colitis • 2017
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