Boosting antibody developability through rational sequence optimization.

@article{Seeliger2015BoostingAD,
  title={Boosting antibody developability through rational sequence optimization.},
  author={Daniel Seeliger and P. Schulz and Tobias Litzenburger and Julia Spitz and Stefan Hoerer and Michaela Blech and Barbara Enenkel and Joey M. Studts and Patrick Garidel and Anne R. Karow},
  journal={mAbs},
  year={2015},
  volume={7 3},
  pages={505-15}
}
The application of monoclonal antibodies as commercial therapeutics poses substantial demands on stability and properties of an antibody. Therapeutic molecules that exhibit favorable properties increase the success rate in development. However, it is not yet fully understood how the protein sequences of an antibody translates into favorable in vitro molecule properties. In this work, computational design strategies based on heuristic sequence analysis were used to systematically modify an… CONTINUE READING
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