Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control

@article{Strickland2011BoostingAT,
  title={Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma control},
  author={Deborah H. Strickland and Stephanie L Judd and Jenny A. Thomas and Alexander N. Larcombe and Peter D. Sly and Patrick G. Holt},
  journal={Mucosal Immunology},
  year={2011},
  volume={4},
  pages={43-52}
}
The hallmark of atopic asthma is transient airways hyperresponsiveness (AHR) preceded by aeroallergen-induced Th-cell activation. This is preceded by upregulation of CD86 on resident airway dendritic cells (DCs) that normally lack competence in T-cell triggering. Moreover, AHR duration is controlled via T-regulatory (Treg) cells, which can attenuate CD86 upregulation on DC. We show that airway mucosal Treg/DC interaction represents an accessible therapeutic target for asthma control. Notably… CONTINUE READING