Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy

@article{Yonezawa2015BoostingCI,
  title={Boosting Cancer Immunotherapy with Anti-CD137 Antibody Therapy},
  author={A. Yonezawa and Suparna Dutt and C. Chester and Jeewon Kim and H. Kohrt},
  journal={Clinical Cancer Research},
  year={2015},
  volume={21},
  pages={3113 - 3120}
}
  • A. Yonezawa, Suparna Dutt, +2 authors H. Kohrt
  • Published 2015
  • Medicine
  • Clinical Cancer Research
  • In the past 5 years, immunomodulatory antibodies have revolutionized cancer immunotherapy. CD137, a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses. CD137 helps regulate the activation of many immune cells, including CD4+ T cells, CD8+ T cells, dendritic cells, and natural killer cells. Recent studies indicate that the antitumor efficacy of therapeutic tumor-targeting antibodies can be augmented by the addition of… CONTINUE READING
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