Boolean versus continuous dynamics in modules with two feedback loops.

@article{Ackermann2012BooleanVC,
  title={Boolean versus continuous dynamics in modules with two feedback loops.},
  author={Eva Ackermann and Eva Marie Weiel and Torsten Pfaff and Barbara Drossel},
  journal={The European physical journal. E, Soft matter},
  year={2012},
  volume={35 10},
  pages={107}
}
We investigate the dynamical behavior of simple networks, namely loops with an additional internal regulating connection. Continuous dynamics for mRNA and protein concentrations is compared to a Boolean model for gene activity. Using a generalized method and within a single framework, we study different continuous models and different types of regulatory functions, and establish conditions under which the system can display stable oscillations or stable fixed points. These conditions depend… CONTINUE READING