Boolean network inference from time series data incorporating prior biological knowledge

@inproceedings{Haider2012BooleanNI,
  title={Boolean network inference from time series data incorporating prior biological knowledge},
  author={Saad Haider and Ranadip Pal},
  booktitle={BMC Genomics},
  year={2012}
}
Numerous approaches exist for modeling of genetic regulatory networks (GRNs) but the low sampling rates often employed in biological studies prevents the inference of detailed models from experimental data. In this paper, we analyze the issues involved in estimating a model of a GRN from single cell line time series data with limited time points. We present an inference approach for a Boolean Network (BN) model of a GRN from limited transcriptomic or proteomic time series data based on prior… CONTINUE READING