Boolean network-based analysis of the apoptosis network: irreversible apoptosis and stable surviving.

@article{Mai2009BooleanNA,
  title={Boolean network-based analysis of the apoptosis network: irreversible apoptosis and stable surviving.},
  author={Zhongxing Mai and Hongmei Liu},
  journal={Journal of theoretical biology},
  year={2009},
  volume={259 4},
  pages={760-9}
}
To understand the design principles of the molecular interaction network associated with the irreversibility of cell apoptosis and the stability of cell surviving, we constructed a Boolean network integrating both the intrinsic and extrinsic pro-apoptotic pathways with pro-survival signal transduction pathways. We performed statistical analyses of the dependences of cell fate on initial states and on input signals. The analyses reproduced the well-known pro- and anti-apoptotic effects of key… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
39 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway

  • W. H. Kim, Lee, J.W
  • Cell Signal
  • 2005
Highly Influential
5 Excerpts

Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

  • J. G. Albeck, Burke, J.M
  • Mol. Cell
  • 2008
3 Excerpts

Similar Papers

Loading similar papers…