Bone tissue remodeling and development: focus on matrix metalloproteinase functions.

@article{Paiva2014BoneTR,
  title={Bone tissue remodeling and development: focus on matrix metalloproteinase functions.},
  author={Kati{\'u}cia Batista da Silva Paiva and Jos{\'e} Mauro Granjeiro},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={561},
  pages={74-87}
}
Bone-forming cells originate from distinct embryological layers, mesoderm (axial and appendicular bones) and ectoderm (precursor of neural crest cells, which mainly form facial bones). These cells will develop bones by two principal mechanisms: intramembranous and endochondral ossification. In both cases, condensation of multipotent mesenchymal cells occurs, at the site of the future bone, which differentiate into bone and cartilage-forming cells. During long bone development, an initial… CONTINUE READING
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