Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: the local implication of osteoclasts and macrophages.

@article{Gamblin2014BoneTF,
  title={Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: the local implication of osteoclasts and macrophages.},
  author={Anne-laure Gamblin and Meadhbh A{\'i}n Brennan and Audrey Renaud and Hideo Yagita and Fr{\'e}d{\'e}ric L{\'e}zot and Dominique Heymann and Val{\'e}rie Trichet and Pierre Layrolle},
  journal={Biomaterials},
  year={2014},
  volume={35 36},
  pages={
          9660-7
        }
}
Human mesenchymal stem cells (hMSC) have immunomodulative properties and, associated with calcium phosphate (CaP) ceramics, induce bone tissue repair. However, the mechanisms of osteoinduction by hMSC with CaP are not clearly established, in particular the role of osteoclasts and macrophages. Biphasic calcium phosphate (BCP) particles were implanted with or without hMSC in the paratibial muscles of nude mice. hMSC increased osteoblastic gene expression at 1 week, the presence of macrophages at… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 37 REFERENCES