Bone tissue engineering with a collagen-hydroxyapatite scaffold and culture expanded bone marrow stromal cells.

@article{Villa2015BoneTE,
  title={Bone tissue engineering with a collagen-hydroxyapatite scaffold and culture expanded bone marrow stromal cells.},
  author={Max M. Villa and Lei Wang and Jianping Huang and David W. Rowe and Mei Y. Wei},
  journal={Journal of biomedical materials research. Part B, Applied biomaterials},
  year={2015},
  volume={103 2},
  pages={243-53}
}
Osteoprogenitor cells combined with supportive biomaterials represent a promising approach to advance the standard of care for bone grafting procedures. However, this approach faces challenges, including inconsistent bone formation, cell survival in the implant, and appropriate biomaterial degradation. We have developed a collagen-hydroxyapatite (HA) scaffold that supports consistent osteogenesis by donor-derived osteoprogenitors, and is more easily degraded than a pure ceramic scaffold. Herein… CONTINUE READING
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