Bone tissue engineering by gene delivery.

@article{Kofron2006BoneTE,
  title={Bone tissue engineering by gene delivery.},
  author={Michelle D. Kofron and Cato Laurencin},
  journal={Advanced drug delivery reviews},
  year={2006},
  volume={58 4},
  pages={
          555-76
        }
}
Recombinant human bone morphogenetic protein-2 and -7 were recently granted United States Food and Drug Administration approval for select clinical applications in bone repair. While significant progress has been made in the delivery of recombinant osteogenic factor to promote bone healing, the short half-life and instability of the protein requires the delivery of milligram quantities of factor or multiple dosages. The potential of gene therapy for bone regeneration is the delivery of… CONTINUE READING
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