Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management

@inproceedings{Grado2018BoneSA,
  title={Bone substitutes: a review of their characteristics, clinical use, and perspectives for large bone defects management},
  author={Gabriel Fernandez de Grado and Laetitia Keller and Ysia Idoux-Gillet and Quentin Wagner and Anne-Marie Musset and Nadia Benkirane-Jessel and Fabien Bornert and Damien Offner},
  booktitle={Journal of tissue engineering},
  year={2018}
}
Bone replacement might have been practiced for centuries with various materials of natural origin, but had rarely met success until the late 19th century. Nowadays, many different bone substitutes can be used. They can be either derived from biological products such as demineralized bone matrix, platelet-rich plasma, hydroxyapatite, adjunction of growth factors (like bone morphogenetic protein) or synthetic such as calcium sulfate, tri-calcium phosphate ceramics, bioactive glasses, or polymer… CONTINUE READING
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