Bone sialoprotein and its transcriptional regulatory mechanism.

  title={Bone sialoprotein and its transcriptional regulatory mechanism.},
  author={Yorimasa Ogata},
  journal={Journal of periodontal research},
  volume={43 2},
BACKGROUND AND OBJECTIVE Bone sialoprotein is a mineralized tissue-specific noncollagenous protein that is glycosylated, phosphorylated and sulfated. The temporo-spatial deposition of bone sialoprotein into the extracellular matrix of bone, and the ability of bone sialoprotein to nucleate hydroxyapatite crystal formation, indicates a potential role for bone sialoprotein in the initial mineralization of bone, dentin and cementum. Bone sialoprotein is also expressed in breast, lung, thyroid and… CONTINUE READING


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