Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition for the Late Effects Study Group.

@article{Meadows1980BoneSA,
  title={Bone sarcoma as a second malignant neoplasm in children: influence of radiation and genetic predisposition for the Late Effects Study Group.},
  author={Anna T. Meadows and Louise C. Strong and Frederick P. Li and Giulio J D'angio and O. Schweisguth and Arnold I. Freeman and R. D. T. Jenkin and Pat Morris-Jones and Mark E. Nesbit},
  journal={Cancer},
  year={1980},
  volume={46 12},
  pages={2603-6}
}
Osteosarcoma or chondrosarcoma developed as a second malignant neoplasm (SMN) in 40 of 188 individuals with SMN whose first neoplasm occurred in childhood. A genetic susceptibility to cancer was found in 23; the SMN developed in an irradiated field in 32; both factors wer present in 16; neither in one. When a genetic predisposition was present, radiation shortened the interval to SMN. The intervals between tumors and the age at which the bone sarcomas developed in relation to genetic disease… CONTINUE READING