Bone-resorbing cytokines in serum of patients with aseptic loosening of hip prostheses.

@article{Granchi1998BoneresorbingCI,
  title={Bone-resorbing cytokines in serum of patients with aseptic loosening of hip prostheses.},
  author={Donatella Granchi and Elisabetta Verri and Gabriela Ciapetti and Susanna Stea and Lucia Maria Savarino and Alessandra Sudanese and Michele Mieti and Roberto Rotini and Dante Dallari and Gian Franco Zinghi and Lucio Montanaro},
  journal={The Journal of bone and joint surgery. British volume},
  year={1998},
  volume={80 5},
  pages={
          912-7
        }
}
Our aim was to determine if the serum levels of bone-resorbing cytokines (IL-1beta, TNF-alpha, IL-6, GM-CSF) are altered in patients with aseptic loosening of a total hip prosthesis, and if such levels are influenced by the type of implant. We determined cytokine levels in sera from 35 patients before revision for failed total hip arthroplasty and compared them with those in 25 healthy donors. We also assessed the soluble receptor of interleukin-2 (sIL-2r) in serum as an indication of a… CONTINUE READING

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