Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue.

@article{Delaisse1988BoneresorbingAA,
  title={Bone-resorbing agents affect the production and distribution of procollagenase as well as the activity of collagenase in bone tissue.},
  author={Jm. Delaisse and Yves Eeckhout and Gilbert Vaes},
  journal={Endocrinology},
  year={1988},
  volume={123 1},
  pages={
          264-76
        }
}
The participation of collagenase in bone resorption has been investigated by assaying the procollagenase extracted from fetal mouse calvaria cultured under a variety of conditions, and by evaluating its ability to degrade bone collagen. Procollagenase was found in two separate pools, one requiring demineralization for its extraction, the other not. Culturing the bones with PTH, 1,25-dihydroxyvitamin D3, prostaglandin E2, interleukin-1, tumor necrosis factor-alpha, catabolin, retinoic acid, or… CONTINUE READING

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