Bone regeneration via a mineral substrate and induced angiogenesis.

  title={Bone regeneration via a mineral substrate and induced angiogenesis.},
  author={William L Murphy and C A Simmons and Darnell Kaigler and David J Mooney},
  journal={Journal of dental research},
  volume={83 3},
Angiogenesis and biomineral substrates play major roles in bone development and regeneration. We hypothesized that macroporous scaffolds of biomineralized 85:15 poly(lactide-co-glycolide), which locally release vascular endothelial growth factor-165 (VEGF), would direct simultaneous regeneration of bone and vascular tissue. The presence of a bone-like biomineral substrate significantly increased regeneration of osteoid matrix (32 +/- 7% of total tissue area; mean +/- SD; p < 0.05) and… CONTINUE READING
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