Bone necrosis of the jaws associated with bisphosphonate treatment: a report of twenty-nine cases.

@article{Merigo2006BoneNO,
  title={Bone necrosis of the jaws associated with bisphosphonate treatment: a report of twenty-nine cases.},
  author={Elisabetta Merigo and Maddalena Manfredi and Marco Meleti and Rebecca Guidotti and Alessandro Ripasarti and Elisa Zanzucchi and Pietro D'Aleo and Domenico Corradi and Luigi Corcione and Enrico Sesenna and Silvano Ferrari and Tito Poli and Mauro Bonaninil and Paolo Vescovi},
  journal={Acta bio-medica : Atenei Parmensis},
  year={2006},
  volume={77 2},
  pages={109-17}
}
Bone necrosis of the jaws is often related to head and neck radiotherapy, to surgical procedures at maxillary or mandibular level but also to various local and systemic factors such as haematological diseases, haemoglobinopathies and systemic lupus eritematosus; its pathogenesis maybe associated with defects of vascularization. Bisphosphonate are synthetic analogues of pyrophosphate used for the treatment of hypercalcemia in patients with malignancies and bone metastasis and for the treatment… CONTINUE READING